Insulin and Diet Therapy of Prior Gestational Diabetes and its effects on Inflammatory Markers Postpartum

Background: Latest studies have presented that elevated interleukin-۶ (IL-۶) and C-reactive protein (CRP), and TNFα may aggravate insulin resistance in pregnancy and contribute to the pathogenesis of type ۲ diabetes mellitus after delivery. This study aimed at the relationship between inflammation markers and diet and insulin therapy in patients with prior gestational diabetes mellitus six weeks postpartum. Fasting blood glucose, A۱C, and C-reactive protein (CRP) were measured. The mean FBS, A۱C, and CRP levels in women with PGDM (insulin and diet therapy) were significantly higher than the healthy non- PGDM group. However, there were no differences between TNFα and IL۶ expressions in these three groups. Elevated FBS, A۱C, and CRP levels in patients with prior GDM may be predictors of progression to T۲DM. Although, the typical route of variation in serum inflammatory markers in the postpartum is not fully determined.

کلیدواژه ها:

C-reactive protein (CRP) ، Interleukin-۶ ، TNFα ، Gestational diabetes mellitus