Background: Hospital-acquired infections (HAIs) are major health issues that increase mortality rates, health-care costs, and hospital stay durations. Simulation-based training (SBT) has emerged as an innovative approach to improving healthcare workers' skills in controlling hospital infections. This paper examines the impact of SBT on adhering to health protocols and reducing hospital-acquired infections. Materials and Methods: A systematic review was conducted using published articles from databases including Cochrane Library, PubMed, Scopus, Web of Science, CINAHL, Embase, PROSPERO, SID, and Google Scholar. The search covered studies from ۲۰۱۴ to ۲۰۲۴. Studies evaluating the impact of simulation-based training on hospital infection control were selected. Different types of training interventions, such as low-fidelity simulators (e.g., mannequins) and high-fidelity simulators (e.g., virtual reality), were analyzed. Studies with high quality, appropriate design, and the use of valid educational tools were included. Quality assessment tools like AMSTAR and the Cochrane Risk of Bias Tool were used, showing that most studies had acceptable quality in reporting. Results: The results showed that simulation-based training in hospitals significantly improved adherence to health protocols and reduced hospital-acquired infections. Particularly in areas like sterilization techniques and proper use of personal protective equipment (PPE), simulations enhanced healthcare workers' skills. High-fidelity simulations, such as virtual reality, were particularly effective in training staff in PPE usage and infection prevention protocols in critical situations. These simulations, especially for training on central venous catheter (CVC) insertion and sterilization techniques, led to a decrease in hospital infection rates. Additionally, these training programs boosted staff confidence and teamwork during infectious disease outbreaks like COVID-۱۹. Conclusion: Simulation-based training is an effective method for controlling hospital-acquired infections. It improves adherence to protocols and reduces infections, particularly in areas such as PPE usage and sterilization techniques. However, despite its proven effectiveness, SBT is not widely implemented in many hospitals. It is recommended that simulation-based training be incorporated into formal hospital education programs to enhance awareness and skills in controlling hospital-acquired infections.
