Impact of Outdoor Particulate Matter (PM۲.۵ and PM۱۰) Exposure on Diagnostic Biomarkers in patients with Chronic Obstructive Pulmonary Disease

Introduction: Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases that significantly increases the mortality rate. Air pollution is a known risk factor for lung diseases including asthma and COPD. People who have more contact with air pollutants are more likely to develop COPD. This study was conducted with the aim of relating particulate matter (PM) with clinical and laboratory diagnostic markers in patients with COPD. Methods: In this cross-sectional analytical study, after obtaining the necessary permits, by referring to the medical records department, hospital information system (HIS) and reviewing the files of patients hospitalized in Abadan and Khorramshahr educational hospitals, information on ۲۷۰ patients with COPD  was obtained. Information about the amount of PM, from March ۲۱, ۲۰۲۲, to March ۲۰, ۲۰۲۳, was received from the Abadan Environment Department. To examine the relationship between PM۱۰ and PM۲.۵ and clinical as well as laboratory variables, multiple linear regression analyses were performed.  The data was entered into Excel software and the results were analyzed in SPSS software.  Results: The results showed that among laboratory and clinical markers, blood urea nitrogen (BUN) ۲۲.۹۹ ± ۱۳.۹۹, blood sugar (BS) ۱۴۸.۱۶ ± ۸۳.۰۴, prothrombin time (PT) ۱۴.۱۸ ± ۴.۶۴, alkaline phosphatase (ALP) ۲۴۹.۴۹ ± ۶۷.۲۱ and erythrocyte sedimentation rate (ESR) ۳۴.۴۷±۲۴.۲۲  were higher than the normal mean and oxygen saturation ) SpO۲ ( ۹۰.۱۹±۸.۲۸ was lower than the normal mean in COPD patients. Also, a significant relationship was found between BS (P=۰.۰۰۱), Alanine transaminase (ALT)(P=۰.۰۱۶) and ESR (P=۰.۰۳۹) with PM۲.۵. Conclusion: In patients with COPD, some kidney, liver, and inflammatory laboratory markers were abnormal. A significant link was found between PM and markers like blood sugar, ALT, and ESR.  Implementing air pollution control is vital for the health of these patients, especially on high pollution days.

کلیدواژه ها:

Pulmonary Disease ، Particulate Matter ، Biomarkers