Background: Adenocarcinoma is a malignant tumor originating from glandular and epithelial tissue. This neoplasm can occur in various organs of the body, including the gastrointestinal tract of dogs, and may affect the stomach, small intestine, large intestine, and rectum. Studies indicate that this disease is more prevalent in older and male dogs, particularly among breeds such as French Bulldogs۱, Golden Retrievers, and German Shepherds. Recent reports have shown a statistically higher incidence in these breeds. Case History: A ۷-year-old, neutered male indigenous dog presented to the veterinary clinic with clinical signs of anorexia and dysphagia. To further investigate, radiographs of the neck and abdomen were obtained. The initial diagnosis was intestinal obstruction; therefore, exploratory laparotomy was carried out. During surgery, extensive adhesions between intestinal loops and fecal leakage on the mesentery throughout the intestines were observed and at the owner’s request the animal was euthanized. The samples were submitted to the pathology laboratory and processed routinely for microscopic examination. Results: Neoplastic epithelial cells formed glandular and acinar patterns consistent with adenocarcinoma. Invasion into the lamina propria, submucosa, and muscularis propria (muscularis externa) was observed. Neoplastic cells had hyperchromatic nuclei and prominent nucleoli. According to microscopic characteristics intestinal adenocarcinoma was diagnosed. Conclusion:
Intestinal adenocarcinoma in dogs, while relatively uncommon, presents with variable clinical signs and progressive invasive behavior. Histopathologic evaluation remains essential for definitive diagnosis, grading, and assessment of invasion and margin status, which together inform prognosis and guide management decisions. Further studies are warranted to optimize diagnostic strategies and evaluate adjuvant therapies to improve survival and quality of life and routine comprehensive checkups and prompt attention in cases with similar clinical signs can lead to earlier diagnosis and improved outcomes.