Enzootic Nasal Adenocarcinoma in a Pregnant Ewe: Clinical, Radiographic, and Histopathologic Findings

Background: Enzootic nasal adenocarcinoma (ENA) is a rare, contagious upper respiratory tumor in sheep and goats caused by enzootic nasal tumor virus (ENTV). Clinical signs are often subtle until advanced stages, and data on ENA in pregnant ewes are limited. Methods: A flock of ۳۰۰ ewes was evaluated due to persistent nasal discharge in pregnant animals. Clinical examination, hematology, skull radiography, necropsy, and histopathology were performed to diagnose and characterize the nasal lesion. Results: The affected ewe exhibited unilateral nasal discharge, dyspnea, stertorous breathing, and conjunctival congestion. Hematology revealed mild anemia, thrombocytopenia, and eosinophilia. Radiographs showed a soft-tissue mass in the left nasal cavity. Necropsy revealed a firm, lobulated, gray-white mass extending from the ethmoidal region. Histopathology confirmed well-differentiated tubular and papillary adenocarcinoma with fibrovascular stroma, consistent with ENA. Clinical signs did not respond to antiparasitic or antibiotic therapy, supporting viral etiology. Conclusion: This case highlights clinical, hematologic, radiographic, and histopathologic features of ENA in a mature, multiparous, pregnant ewe. Early recognition, imaging evaluation, and histopathological confirmation are essential for managing affected flocks. Preventive measures remain critical due to the lack of effective treatment.

کلیدواژه ها:

Enzootic nasal adenocarcinoma ، ENTV ، Sheep ، Nasal tumor ، Histopathology