Immuno-Nanotechnology in Veterinary Wound Healing: Integrating Nanomaterials with Host Immune Modulation (۲۰۲۲-۲۰۲۵)

Background: Recent advances in immuno-nanotechnology show how nanomaterials can modulate host immune responses during tissue repair. This is important because managing cutaneous wounds in veterinary medicine faces serious challenges, mainly from multidrug-resistant (MDR) pathogens and the limits of our current therapies. Nanotechnology, engineering materials at the ۱–۱۰۰ nm scale, offers a way to fundamentally change tissue repair. It lets us design active, multi-functional platforms that can help orchestrate the healing process. This review synthesizes the current evidence for these nano-based solutions in veterinary wound healing and surgical adhesion. Methods: We conducted a systematic literature search of PubMed, Scopus, and Web of Science for peer-reviewed articles published between January ۲۰۲۲ and December ۲۰۲۵. The search focused on the design, characterization, and application of nanomaterials for cutaneous wound healing and surgical bioadhesives in veterinary species or relevant preclinical animal models. Results: The evidence reveals a sophisticated evolution. We've moved from single-function antimicrobial agents, like silver nanoparticles (AgNPs), to multi-modal platforms that actively promote regeneration. Key nanomaterials including metallic nanoparticles (gold, zinc oxide), polymeric scaffolds (chitosan), and lipid-based nanocarriers demonstrate potent antimicrobial, anti-inflammatory, and pro-angiogenic properties in preclinical settings. Nano enhanced surgical adhesives also appear to overcome the traditional tradeoff between adhesion strength and biocompatibility, creating strong sealants that have integrated therapeutic capabilities. Conclusion: Nanotechnology holds immense potential to revolutionize veterinary wound care. But a significant "translational chasm" still separates this promising lab data (mostly from rodents) from validated clinical trials in target veterinary species. Bridging this gap isn't simple. It demands a concerted effort to address key challenges in species-specific nanotoxicology, tangled regulatory frameworks, and economic viability. Future research must pivot to clinical trials in target species, develop standardized safety protocols, and advance next gen platforms like stimuli responsive materials to realize the full clinical potential of this technology.

کلیدواژه ها:

Nanotechnology ، Veterinary Medicine ، Wound Healing ، Nanoparticles ، Surgical Adhesives