Comparison of the Tumor-Suppressing Effects of Aqueous and Hydroalcoholic Extracts of Pomegranate Peel on Gastric Cancer

Background: The active compounds of pomegranate peel (PP) have different effects and their solubility varies based on their polarity. There are limited studies that thoroughly examine and compare the effects of hydroalcoholic and aqueous extracts of its components so this study will investigate which extract (aqueous or hydroalcoholic) has a greater effect on gastric cancer cells (AGS cell line). Methods: Gastric cancer cell line (AGS) used and subjected to different concentrations of aqueous or hydroalcoholic extract of PPE, from ۰.۲۵ to ۸ mg/ml then viability, and IC۵۰ assays were performed. Results: In our study, both aqueous and hydroalcoholic extracts of pomegranate peel exhibited anti-tumor properties against AGS cells (p ≤ ۰.۰۱). The IC۵۰ value of the aqueous extract was determined to be ۲.۷۸۴ mg/mL, indicating a higher potency in inhibiting gastric cancer cell proliferation. In comparison, the hydroalcoholic extract exhibited a higher IC۵۰ value of ۳.۵۸۸۵۶ mg/mL, suggesting it is less effective at the same concentration. Conclusion: Therefore, the aqueous extract demonstrates a stronger cytotoxic effect against gastric cancer cells compared to the hydroalcoholic extract.

کلیدواژه ها:

AGS ، Pomegranate ، Gastric cancer ، MTT