Efficient green synthesis of 3,3-di(indolyl)indolin-2-ones using sulfonic acid functionalized nanoporous SBA-Pr-SO3H and study of their antimicrobial properties

SBA-Pr-SO3H with pore size of 6 nm was found to be a green and effective solid acid catalyst in reaction of isatin with indoles under mild reaction conditions to afford a novel class of symmetrical 3,3-di(indolyl)indolin-2-ones in excellent yields. The antimicrobial activities of synthesized compounds have been tested. Antimicrobial tests showed that the MIC value of compound 3e against B. subtilis was equal to that of Chloramphenicol.

کلیدواژه ها:

3 ، 3-di(indolyl)indolin-2-ones ، Multicomponent reaction ، Isatin ، Nano-reactor ، Functionalized SBA-15 ، Antimicrobial activity