Antioxidant Activity of Capsaicin on LS-۱۸۰ Cell Line

Cancer is one of the main causes of premature death in the world, and oxidative stress plays an important role in the pathogenesis of this disease. Since there is much evidence about the anticancer effect of antioxidants, this study aims to investigate the effect of capsaicin on the activity of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase in the LS-۱۸۰ human colorectal cancer cell line.In this study, the human colorectal cancer cell line (LS-۱۸۰) was treated with different concentrations of capsaicin for ۲۴ hours, and then the activities of the antioxidant enzymes of superoxide dismutase, catalase, and glutathione peroxidase were determined by calorimetric methods. Analysis of the results showed that the activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes increased in capsaicin-treated groups compared to the control group in the LS-۱۸۰ cell line (p<۰.۰۵). Capsaicin inhibits cell proliferation by increasing the activity of antioxidant enzymes.

کلیدواژه ها:

capsaicin ، Antioxidant activity ، LS-۱۸۰ cell line