Investigating the impact of radon therapy in water and air on the population density of stem cells

Despite the established negative effects of radon on lung and skin cancers, radon therapy has historically been considered a potential treatment for various skin and respiratory diseases. In this study, the impact of such therapy on the population density of hematopoietic stem cells, including both WT and Lnk types, which are crucial for regenerative medicine, was investigated. MCNPX simulations were used to perform dosimetry for radon in a MIRD phantom. The calculated dose rates for both air and water were integrated into a stem cell differential equation, which was solved using the robust fourth-order Runge-Kutta method to model changes over a four-day period. It was shown that the radon dose reduces the population density of stem cells. This minimal reduction suggests that low-dose radon exposure does not have a destructive effect on stem cells, but rather a tolerable one. By the end of day ۴, the stem cell density was observed to have decreased by ۱۲.۳۳% in the air environment and ۲.۶۵% in the water environment, suggesting a more pronounced effect in the air scenario.

کلیدواژه ها:

radon ، Radon Therapy ، Dosimetry ، MIRD Phantom ، MCNPX ، Fourth-Order Runge-Kutta ، stem cells