Synthesis and Characterization of Ag@ZIF -۸ and Investigation of Its Performance as a Controlled Drug Delivery System

Metal-organic frameworks (MOFs) are a class of porous crystalline materials formed through the coordination of metal ions with organic ligands. Their high surface area, adjustable porosity, and chemical stability have made them attractive candidates for drug delivery applications. Among MOFs, Zeolitic Imidazolate Framework-۸ (ZIF-۸) stands out due to its pH-sensitive degradability, tunable pore size, and excellent biocompatibility, making it especially suitable for targeted therapeutic delivery. In parallel, noble metal nanoparticles such as silver (AgNPs), gold (AuNPs), and platinum exhibit unique physicochemical properties including strong surface plasmon resonance, high catalytic activity, and notable biocompatibility. When embedded within MOFs, these nanoparticles can synergistically enhance the functionality and therapeutic efficacy of the composite systems. In particular, the integration of AgNPs into ZIF-۸ structures improves the antibacterial and anticancer potential while preventing nanoparticle agglomeration. ۶-Mercaptopurine (۶-MP) is an established chemotherapeutic agent used in the treatment of leukemia and autoimmune disorders. However, its clinical use is limited by poor solubility, rapid metabolism, and potential toxicity. In this study, a novel Ag@ZIF-۸ nanocomposite was synthesized for the controlled delivery of ۶-MP. Silver nanoparticles were embedded into the ZIF-۸ matrix during synthesis to ensure uniform distribution and structural integrity. ۶-MP was subsequently loaded onto the composite via coordination and electrostatic interactions. Characterization techniques including FTIR, XRD, CHNS, SEM, and TGA confirmed the successful fabrication of the composite and effective drug loading. In vitro release studies at pH ۴.۸ and ۷.۴ demonstrated a sustained and controlled release over ۴۸ hours. The results highlight the Ag@ZIF-۸/۶-MP composite as a promising platform for targeted and controlled anticancer drug delivery.

کلیدواژه ها:

Metal –Organic Frameworks ، Zeolitic Imidazolate Framework-۸ ، Silver Nanoparticles ، Targeted Drug Delivery