One-Pot Three-Component Synthesis of ۴,۴`-((Phenyl)methylene) bis(۳-methyl-۱-phenyl-۱H-Pyrazole-۵-ol) Derivatives under Solventless Conditions by Using a New, Efficient and Heterogenous Hybrid Nanocatalyst

Pyrazoles, due to its nitrogen containing five membered heterocyclic moieties are as one of important heterocycle compound in the pharmaceutical production. They are applied in many cases such as anti-inflammatory, antimicrobial, and antitumor. A range of catalysts and reagents have been used for the synthesis of pyrazoles. In this work, we prepared ۴,۴`-((phenyl)methylene) bis(۳-methyl-۱-phenyl-۱H-pyrazole-۵-ol) in the condition of solvent-free, through treatment of phenylhydrazine and ethyl acetoacetate with the corresponding aromatic aldehydes in one-pot three-component condensation in the presence a new, efficient, heterogeneous hybrid nanocatalyst based on zeolite with high yield. Results of investigation about catalytic activity of this new hybrid nanocatalytic were showed low reaction times, simple work-up, easy of recovery and reusability of reaction with good yield.

کلیدواژه ها:

Hybrid nanocatalyst ، Pyrazole ، Solventless ، Heterogenous