Preparation of Fe۳O۴/SBA-۱۶-NH۲ magnetic nanocomposite and investigation of phenobarbital drug absorption kinetics

In this study, the kinetics of phenobarbital drug adsorption on Fe۳O۴/SBA-۱۶-NH۲ magnetic nanocomposite as a drug carrier was investigated. For this purpose, in the first step, the SBA-۱۶-NH۲ mesostructure was synthesized using Pluronic F۱۲۷ as a structure-determining agent and ۳-aminopropyltriethoxysilane. XRD and FT-IR analyses were performed on the synthesized sample. After the correctness of the mesostructure was confirmed, magnetic F۳O۴ nanoparticles were synthesized using FeCl۳.۶H۲O and FeCl۲.۴H۲O salts and these nanoparticles were loaded onto the SBA-۱۶-NH۲ mesostructure in order to magnetize the mesostructure. Again, the magnetic nanocomposite was subjected to XRD, FTIR, SEM, TEM, BET and EDX. Then, the kinetics of phenobarbital drug absorption on the synthesized magnetic nanocomposite was investigated. In the second stage, using the design of experiments (DOE) software using the response surface methodology (RSM) and central composite model (CCD), the effect of effective parameters on the drug absorption process, including pH, contact time, temperature, drug concentration, and nanocarrier dose, was studied and the optimal value for each parameter was obtained. Finally, to find the best kinetic model, four zero-order, pseudo-first-order, pseudo-second-order, and Higuchi models were studied under optimal conditions. The results showed that the loading process of phenobarbital drug on the magnetic nanocomposite Fe۳O۴/SBA-۱۶-NH۲ corresponds to the pseudo-first-order kinetic model with a regression coefficient of R۲ = ۰.۹۹۵۲.

کلیدواژه ها:

Response Surface Methodology ، Phenobarbital ، Magnetic nanoparticles ، Smart drug delivery systems ، Nanocarrier