Association between matrix metalloproteinase-۹ polymorphism and the risk of preeclampsia: Evidence from an updated meta-analysis

Background: Preeclampsia (PE), a prevalent form of hypertension disorder of pregnancy, is diagnosed by an elevation in hypertension coexistence with proteinuria. Several studies examined the impact of MMP-۹-۱۵۶۲ (matrix metalloproteinase) polymorphism on PE risk in different countries; however, results were inconsistent. Objective: The aim of the current meta-analysis was to explore the association between MMP-۹-۱۵۶۲ polymorphism and PE susceptibility. Materials and Methods: To carry out the current meta-analysis study, eligible research was identified through databases such as Scopus, PubMed, and Google Scholar. Eligible studies were defined as case-control or cohort studies to examine the role of MMP-۹-۱۵۶۲ polymorphism on PE development, with access to information on genotype frequencies in both cases and controls. For data analysis, the MetaGenyo web tool was used. Results: Findings indicated that the MMP-۹-۱۵۶۲ variant is correlated with an increased risk of PE in dominant, overdominant, and codominant heterozygous models. Subgroup analysis by ethnicity showed the elevated risk of PE in the Brazilian ethnicity in overdominant and codominant heterozygous models. Heterogeneity was observed between studies in allelic, dominant, overdominant, and codominant heterozygous genetic models. Conclusion: This meta-analysis disclosed that MMP-۹-rs۳۹۱۸۲۴۲ may affect susceptibility to PE.

کلیدواژه ها:

Preeclampsia ، Matrix metalloproteinase ، Single nucleotide polymorphism ، Meta-analysis. ، پره اکلامپسی ، ماتریکس متالوپروتئیناز ۹ ، پلی مورفیسم تک نوکلئوتیدی ، متاآنالیز.