آثار کاربرد هم زمان از پلاکت لیوفیلیزه شده انسانی و امنتوم اتوگرافت در ترمیم استخوان در مدل خرگوش

Abstract Introduction: This study was performed to evaluate the effect of lyophilized human platelet rich plasma powder (LhPRP) and omentum autograft on the bone healing properties in animal model which can further be utilized for different orthopedic or maxillofacial reconstructive surgeries.Materials & Methods: Bone defects of ۱۰ mm diameter were created in diaphysis of radius of ۲۰ rabbits and then either left undisturbed (control group) or filled with one of the following materials: a piece of autogenous omentum, LhPRP, or concurrent use of LhPRP and omentum. Bone formation, union and remodeling, were evaluated at the ۲nd, ۴th, ۶th and ۸th weeks postoperatively by radiography, using bone healing criteria. On ۵۶th postoperative day, the operated limbs were removed and further histopathological evaluations were carried out.Results & Discussion: The results showed that LhPRP with or without omentum in bone regeneration in ۱۰mm defects was significantly superior to control group (p<۰.۰۵).Conclusion: LhPRP powder, alone or combined with autogenic omentum, provides increased bone regenerative properties in experimental bone defects in animal model after ۵۶ days.Keywords: Omentum, Lyophilization, Platelets, Bone regeneration, Rabbits.

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امنتوم ، خشک کردن انجمادی ، پلاکت ها ، بازسازی استخوان ، خرگوش ها