Burn patients are at risk of serious complications, including sepsis, acute respiratory distress syndrome, and organ dysfunction, despite advancements in medical treatment. Early prediction and management of sepsis and acute inflammation and the identification of high-risk patients are crucial for the improvement of outcomes. This study aimed to evaluate the prognostic value of serum albumin, base deficit, and
C-reactive protein (CRP)/albumin ratio (CAR) in severe burn patients.In a retrospective analysis of ۱۹۵ patients with ۲۰%-۸۰% total body surface area (TBSA) burns admitted to the burn intensive care unit (ICU) at Velayat University Hospital from April ۲۰۱۸ to April ۲۰۲۱, serum albumin, base deficit, and CAR were measured upon admission.Significant differences were observed between survivors and non-survivors in terms of serum albumin levels (۳.۰۵±۰.۵۶ vs. ۱.۸۹±۰.۶۹ g/dL), base deficit (۳.۳۶±۲.۱۵ vs. ۱۰.۶۲±۱.۷۱ mmol/l), CRP (۲۰.۹۵±۲۹.۳۳ vs. ۵۴.۶۲±۴۶.۲۹ mg/L), CAR (۷.۷۳±۱۱.۵۲ vs. ۳۶.۸۰±۳۵.۵۹), and length of ICU stay (۲.۷۵±۲.۵۱ vs. ۶.۴۵±۴.۵۰) (P<۰.۰۰۱). Multivariate logistic regression indicated that unlike CRP, serum albumin levels (P=۰.۰۴۵), base deficit (P=۰.۰۰۱), and TBSA (P=۰.۰۴۶) were significantly associated with increased mortality.As evidenced by the obtained results, serum albumin, base deficit, and CAR are linked to adverse outcomes and may be valuable tools for risk stratification, identifying high-risk patients, and guiding early interventions in burn patients. Further research is needed to validate these findings and explore the underlying mechanisms.Burn patients are at risk of serious complications, including sepsis, acute respiratory distress syndrome, and organ dysfunction, despite advancements in medical treatment. Early prediction and management of sepsis and acute inflammation and the identification of high-risk patients are crucial for the improvement of outcomes. This study aimed to evaluate the prognostic value of serum albumin, base deficit, and
C-reactive protein (CRP)/albumin ratio (CAR) in severe burn patients.In a retrospective analysis of ۱۹۵ patients with ۲۰%-۸۰% total body surface area (TBSA) burns admitted to the burn intensive care unit (ICU) at Velayat University Hospital from April ۲۰۱۸ to April ۲۰۲۱, serum albumin, base deficit, and CAR were measured upon admission.Significant differences were observed between survivors and non-survivors in terms of serum albumin levels (۳.۰۵±۰.۵۶ vs. ۱.۸۹±۰.۶۹ g/dL), base deficit (۳.۳۶±۲.۱۵ vs. ۱۰.۶۲±۱.۷۱ mmol/l), CRP (۲۰.۹۵±۲۹.۳۳ vs. ۵۴.۶۲±۴۶.۲۹ mg/L), CAR (۷.۷۳±۱۱.۵۲ vs. ۳۶.۸۰±۳۵.۵۹), and length of ICU stay (۲.۷۵±۲.۵۱ vs. ۶.۴۵±۴.۵۰) (P<۰.۰۰۱). Multivariate logistic regression indicated that unlike CRP, serum albumin levels (P=۰.۰۴۵), base deficit (P=۰.۰۰۱), and TBSA (P=۰.۰۴۶) were significantly associated with increased mortality.As evidenced by the obtained results, serum albumin, base deficit, and CAR are linked to adverse outcomes and may be valuable tools for risk stratification, identifying high-risk patients, and guiding early interventions in burn patients. Further research is needed to validate these findings and explore the underlying mechanisms.
