Biomimetic Wound Dressings: Advancements, Applications, and Challenges in Modern Wound Care

Wound dressings are critical in managing various injuries, including pressure ulcers, venous ulcers, and diabetic foot ulcers. Various dressing materials are employed in wound care, such as traditional dressings, interactive materials, skin substitutes, bioactive dressings, and dermal grafts. These materials, both synthetic and biological, contribute to effective wound healing by supporting the regeneration of skin tissues. However, biomimetic wound dressings are emerging as a superior alternative to conventional dressings due to their ability to align more closely with the natural wound healing process. Among these, hydrogels are particularly promising for their capacity to replicate the biological properties of human skin, offering enhanced moisture retention, flexibility, and biocompatibility. Biomimetic wound dressings are available in various forms, including films, gauzes, injectable gels, and sprays, catering to different wound types and healing stages. In recent years, the development of novel wound dressings has become a focal point in biomedical engineering, with a strong emphasis on leveraging the benefits of biomaterials. These advanced dressings promote faster healing and offer various advantages, such as reduced infection risk and improved patient comfort. However, despite their potential, biomimetic dressings also present specific challenges, such as production costs and variability in performance across different wound types. This review explores the strengths and limitations of biomaterial-based wound dressings, highlighting their growing significance in modern wound care and future therapeutic applications.Wound dressings are critical in managing various injuries, including pressure ulcers, venous ulcers, and diabetic foot ulcers. Various dressing materials are employed in wound care, such as traditional dressings, interactive materials, skin substitutes, bioactive dressings, and dermal grafts. These materials, both synthetic and biological, contribute to effective wound healing by supporting the regeneration of skin tissues. However, biomimetic wound dressings are emerging as a superior alternative to conventional dressings due to their ability to align more closely with the natural wound healing process. Among these, hydrogels are particularly promising for their capacity to replicate the biological properties of human skin, offering enhanced moisture retention, flexibility, and biocompatibility. Biomimetic wound dressings are available in various forms, including films, gauzes, injectable gels, and sprays, catering to different wound types and healing stages. In recent years, the development of novel wound dressings has become a focal point in biomedical engineering, with a strong emphasis on leveraging the benefits of biomaterials. These advanced dressings promote faster healing and offer various advantages, such as reduced infection risk and improved patient comfort. However, despite their potential, biomimetic dressings also present specific challenges, such as production costs and variability in performance across different wound types. This review explores the strengths and limitations of biomaterial-based wound dressings, highlighting their growing significance in modern wound care and future therapeutic applications.

کلیدواژه ها:

Biomaterials ، Biomimetic ، Biopolymers ، Hydrogel ، Skin regeneration ، Wound dressings