Comparison of Two Fluid Therapy Methods with and Without Lasix in Crash Injured Patients with Lung Contusion: A Randomized Clinical Trial

Introduction: There are various approaches to fluid therapy for patients with lung contusions, and managing fluid levels can be crucial to the recovery of these patients. This study was conducted from January to June ۲۰۲۲ to determine the effectiveness of two methods of fluid therapy with and without Lasix in patients with crash injury accompanied by lung contusion. Methods: This clinical trial, conducted at Bahonar Hospital, Kerman, randomly divided patients with crush injury into two groups: recipients of normal saline and recipients of crystalloid plus Lasix. Clinical parameters, including blood pressure, respiratory function, and biochemical markers, were monitored at baseline and every ۳ hours for a period of ۹۶ hours. Results: The Lasix group showed a significantly reduced need for intubation (۲۲.۲% vs ۴۳.۸%, p = ۰.۰۲) and shorter NIV duration (p = ۰.۰۰۸) compared to the control group. Intra-abdominal pressure and PF ratio demonstrated favorable trends in the intervention group (p<۰.۰۱). Significant improvements in CPK, phosphorus, and potassium levels were observed with diuretic therapy (p<۰.۰۵). Conclusion: The addition of Lasix to standard fluid therapy improved respiratory outcomes and metabolic parameters in patients with crush injuries and pulmonary contusions. This combined approach warrants further investigation in larger clinical trials.

کلیدواژه ها:

Crush Injuries ، Contusion ، Trauma ، Fluid Therapy ، Furosemide