Novel Voltammetric Sensor Based on Ionic Liquid and Co-MOF/MWCNTs Nanostructure: Simple and Sensitive Electrochemical Determination of Daunorubicin

A novel electrochemical sensor based on carbon paste electrode (CPE) modified with ionic liquid (IL) and nanostructure of cobalt-۲-amino-۱,۴-benzenedicarboxylic acid metal-organic framework (Co-BDC-NH۲ MOF) and multi-walled carbon nanotubes (MWCNTs) has been designed and applied for voltammetric determination of daunorubicin. The electrochemical analysis of daunorubicin was performed using cyclic voltammetry (CV) studies, chronoamperometry investigations, and differential pulse voltammetry (DPV) measurements. Due to the improved electron transfer rate at the surface of Co-BDC-NH۲ MOF/MWCNTs/ILCPE, the redox peak currents of daunorubicin were higher than other CPEs. From DPV measurements, the Co-BDC-NH۲ MOF/MWCNTs/ILCPE-based electrochemical sensing platform detected daunorubicin in the range of ۰.۰۰۸ µM to ۳۴۰.۰ µM, with the limit of detection (LOD) for daunorubicin being ۰.۰۰۳ µM. Furthermore, the developed sensing platform was efficiently used for the analysis of daunorubicin injection with recoveries in the range of ۹۷.۸% to ۱۰۴.۰% and relative standard deviations (RSDs) less than ۳.۳%.

کلیدواژه ها:

Electrochemical sensor ، Chemotherapy ، Drug analysis ، Modified carbon paste electrode Daunorubicin