Evaluation of the diagnostic efficacy of M۲PK and FIT findings for colorectal cancer screening

Background: The mortality rate of colorectal cancer could be declined by immediate diagnosis. Objectives: We surveyed the potentials of two diagnostic methods, M۲ pyruvate kinase (M۲PK) and fecal immunochemical tests (FIT), in comparison to colonoscopy as the golden standard strategy. Methods: This cross-sectional study was carried out in ۲۰۱۸ in the north of Iran. Stool samples were taken from ۷۶۸ subjects. A total of ۳۸۴ people were tested for M۲PK and ۳۸۴ for FIT. M۲PK was evaluated by ELISA (ScheBo kit, Germany), and the FIT was performed immunologically. Then, Colonoscopy was performed on all people. Finally, sensitivity, specificity, positive, and negative predictive values were computed. Results: The mean age of participants was ۵۱.۵±۱۴. ۶ years. In this population, ۶۸% of people had lesions in colonoscopy. Occult blood in M۲PK and FIT test were ۶۴.۶ (U/ML) and ۶۵.۹ (ng/mL), respectively. The sensitivity, specificity, positive and negative predictive values of M۲PK were ۷۲.۶%, ۸۷.۱۸%, ۸۲.۱%, and ۷۹.۷%, respectively. Correspondingly, the results of FIT were ۶۷.۱%, ۳۷.۱%, ۷۱.۹ %, ۳۲.۰% respectively. Conclusion: This study showed that the M۲PK test had higher sensitivity and specificity compared to FIT. Considering that nowadays non-invasive tests like M۲PK are cost-effective and easy to perform than colonoscopy, they can be used in the first stage of screening and this can be a great step in monitoring individuals and identifying pre-cancerous lesions.

کلیدواژه ها:

M۲PK Test ، FIT Test ، Colonoscopic Findings ، Diagnostic Value