The role of nano-particles in nerve tissue engineering: opportunities and challenges

Neurodegeneration, scar tissue formation, and communication disruption between neurons and cells are the primary concerns associated with nerve damage. Despite advancements, regenerating nerve tissue at the injury site remains a significant hurdle in medical treatment. Nerve tissue engineering presents a promising avenue in regenerative medicine for addressing these challenges in repairing damaged or diseased nervous systems. However, achieving an optimal neural guidance system is still a considerable endeavor. One approach that shows potential in aiding nerve regeneration involves the utilization of nanoparticles. These minute entities, situated at the forefront of nanotechnology, possess unique size-dependent characteristics that offer promise in surmounting numerous obstacles encountered in tissue engineering. They facilitate cell adhesion, proliferation, and differentiation, while also supporting neurite growth—a vital aspect of nerve regeneration. Additionally, nanoparticles serve diverse roles, including nerve guidance, pollution mitigation, transportation of growth factors, and reinforcement of scaffold structures, among others. Various studies have explored the application of nanoparticles. This review focuses on commonly utilized types of nanoparticles and analyzes their advantages and challenges in nerve regeneration.

کلیدواژه ها:

Nanoparticles ، Nerve regeneration ، Tissue engineering ، Nanotechnology