Effect of myo-inositol on the prevention of gestational diabetes in high-risk pregnant women: An RCT

Background: Gestational diabetes mellitus (GDM) is a rising problem which, if not diagnosed and treated in time, can lead to maternal, fetal, and neonatal complications. Therefore, it is very important to consider predisposing factors and prevention of GDM. Objective: This study aims to investigate the effect of myo-inositol (MI) on the prevention of GDM and other pregnancy outcomes. Materials and Methods: This randomized controlled trial was conducted at the Arash Women’s hospital and Yas hospital Complex, Tehran, Iran between November ۲۰۱۹ and May ۲۰۲۰ and included ۱۵۰ women, the study was divided into ۲ groups (n = ۷۵/each). Women received ۴۰۰۰ mg of MI plus ۴۰۰ mg of folic acid daily in the MI group and ۴۰۰ mg of folic acid in the placebo group from ۱۱-۱۴ gestational weeks for ۱۴ wk. Participants underwent ۷۵ gr oral glucose tolerance test at ۲۴-۲۸ wk and were followed up until delivery. Results: After adjustment for confounding factors, MI treatment was associated with a significant reduction of GDM (aRR: ۰.۵۸, ۰.۳۶, ۰.۹۱, p = ۰.۰۲۰). However, no significant difference was observed between the ۲ groups in cases of other pregnancy outcomes and glycemia at each step of oral glucose tolerance test values. Conclusion: Our results showed that MI significantly reduced GDM. With insufficient evidences, more studies with an appropriate sample size are recommended.

کلیدواژه ها:

Gestational diabetes mellitus ، Pregnancy ، Myo-inositol ، Primary prevention. ، دیابت بارداری ، بارداری ، میواینوزیتول ، پیشگیری اولیه.