Preparation and Characterization of α-Tocopherol-Loaded Nano-Lipid Carriers: Effect of Lipid Type and Carrier Oil Content

Nano lipid carriers for encapsulating α-tocopherol (α-TC) were successfully fabricated using the hot homogenization method. The effect of oil content and type of lipid on the physicochemical properties of different formulations were investigated. The results showed that α-TC nanocarriers exhibited a small particle size (۲۵۹.۲-۳۷۹ nm), narrow PolyDispersity Index (PDI) (۰.۱۷۸-۰.۴۳۲), and high Entrapment Efficiency (EE) (۹۵.۷۳-۹۹.۲۲%). Nanostructured Lipid Carrier (NLC) of Compritol containing ۴۵% corn oil (α-TC-NC۴۵) was selected as the optimum formulation due to its smaller particle size as well as PDI and higher EE. The Differential Scanning Calorimetry (DSC) and X-Ray Diffractometry (XRD) data revealed a low degree of crystallinity for α-TC-NC۴۵ with  two crystal forms of α and ß´. Transmission Electron Microscopy (TEM) images also revealed an almost spherical morphology for the particles. The α-TC-NC۴۵ was stable concerning particle size, PDI, and EE during a ۳-month storage at both ۴ and ۲۵ °C. The results suggested that nanostructured lipid carrier of Compritol containing ۴۵% corn oil may be an appropriate delivery system for food and beverage fortification with α-tocopherol.

کلیدواژه ها:

Nanostructured lipid particles ، α-Tocopherol ، encapsulation ، Compritol