The Effect of Estrogen and Progesterone Hormones on Wound Healing in Pregnancy

During pregnancy, the body undergoes significant hormonal changes that can influence various physiological processes, including wound healing. This study aims to investigate the effects of estrogen and progesterone, two pivotal hormones in pregnancy, on the wound healing process. A comprehensive review of current literature was undertaken, focusing on experimental and clinical studies that examine the molecular and cellular mechanisms by which these hormones affect the wound healing phases: hemostasis, inflammation, proliferation, and remodeling. Notably, estrogen is known for its anti-inflammatory properties and its role in promoting angiogenesis and re-epithelialization. Progesterone, on the other hand, has been shown to modulate immune responses and enhance collagen deposition. In our study, we analyzed the healing patterns of incisional wounds in pregnant rodent models treated with varying levels of exogenous estrogen and progesterone. Results indicated a marked improvement in wound closure rates and histological quality of the regenerated tissue in the hormonal treatment groups compared to controls. Specifically, estrogen-treated groups demonstrated accelerated re-epithelialization and increased capillary density, while progesterone-treated groups showed enhanced collagen fiber alignment and tensile strength of the healed tissue. These findings suggest that the elevated levels of estrogen and progesterone during pregnancy may confer a beneficial effect on wound healing, potentially through synergistic actions on various cellular pathways. Understanding these mechanisms can provide insights into therapeutic strategies for improving wound healing outcomes in pregnant patients and possibly other populations with impaired healing capabilities. Our research highlights the necessity for further clinical studies to validate these preclinical findings and explore potential applications in obstetric practice, particularly in the management of surgical and traumatic wounds during pregnancy.

کلیدواژه ها:

Hormones ، Estrogen ، Progesterone ، wound healing ، during pregnancy