Application of Natural Hydrogels in Preventing Adhesions After Surgery in Recent Years: A Review

In recent years, natural hydrogels have attracted significant attention as an effective solution for preventing postoperative adhesions, a common complication following surgical procedures. This review article examines recent findings and advancements in the application of natural hydrogels for adhesion prevention. Hydrogels are recognized as three-dimensional networks of hydrophilic polymers that can swell in water, mimicking the properties of soft tissues. Their ability to retain moisture and create a biocompatible environment makes them ideal candidates for surgical applications. Recent studies emphasize the role of hydrogels in accelerating wound healing, as these materials minimize tissue trauma and inflammation by maintaining moisture and providing optimal conditions for drug delivery. The application of hydrogels in reducing adhesion formation involves creating physical barriers that separate healing tissues while also delivering anti-inflammatory agents directly to the surgical site. Existing evidence indicates that hydrogels not only function as barriers but also facilitate localized drug release, thereby reducing inflammation and promoting tissue regeneration. Recent innovations have led to the development of advanced hydrogel formulations. For instance, the introduction of sprayable hydrogels demonstrates how these materials can be applied directly to surgical sites, providing immediate protection against adhesion formation. This method allows for ease of application and ensures that the hydrogel conforms effectively to irregular surfaces. The significance of using natural polymers such as hyaluronic acid and chitosan in hydrogel formulations is noteworthy. These materials exhibit excellent biocompatibility and possess intrinsic anti-inflammatory properties that contribute to adhesion prevention. The synergistic effects of these natural components enhance the mechanical stability and degradation profiles of hydrogels, making them suitable for prolonged use post-surgery. Ultimately, the use of natural hydrogels is recognized as a promising strategy for preventing postoperative adhesions. The integration of advanced hydrogel technologies with natural biomaterials offers a multifaceted approach to improving surgical outcomes. Future research should focus on optimizing these formulations for specific surgical contexts while ensuring their efficacy and safety in clinical environments. As our understanding of hydrogel mechanisms deepens, their role in postoperative care is expected to expand, potentially revolutionizing standard practices in surgery.

کلیدواژه ها:

Natural hydrogels ، Prevent ، Adhesion ، Surgery