Effect of Different Intensities of Aerobic Exercise Combined with Resistance Exercise and Consumption of Cinnamon on Meteorin-like protein (METRNL) and Irisin in Diabetic Women

Objective: Studies show that exercise and herbal supplements help improves type ۲ diabetes. The aim of this study was to investigate the effect of different intensities aerobic exercise with resistance training and cinnamon on the levels of METRNL and irisin in diabetic women. Materials and Methods: In this clinical trial study, ۵۴ diabetic women (age ۴۱.۷۳± ۴.۰۵) were selected from Nowshahr and randomly allocated into six groups; Control (C), Resistance and Moderate Aerobic Exercise (RME, ۵۰% VO۲max, ۲۰۰ kcal), Resistance and Vigorous Aerobic Exercise (RVE, ۸۰% VO۲max, ۲۰۰ kcal), Cinnamon (Ci, ۱۰۰۰ mg/day), Resistance and Moderate Aerobic Exercise+Cinnamon (RMECi), Resistance and Vigorous Aerobic Exercise+Cinnamon (RVECi). Data were analyzed using an independent t-test and ANCOVA (P< ۰.۰۵). Results: It was observed a significant increase in Metrnl, irisin in the RME (P= ۰.۰۴۱ and P= ۰.۰۰۴, respectively), RVE (P= ۰.۰۰۰۱ and P= ۰.۰۰۰۱, respectively), Ci (P= ۰.۰۰۶ and P= ۰.۰۰۰۱, respectively), RMECi (P= ۰.۰۰ and P= ۰.۰۰۰۱, respectively) and RVECi (P= ۰.۰۰۱ and P= ۰.۰۰۰۱, respectively) compared to group C. The increase in Metrnl and irisin was significant in RVE compared to RME (P= ۰.۰۴۵, and P= ۰.۰۲۸, respectively); RMECi relative to RME (P= ۰.۰۰۴) and Ci (P= ۰.۰۰۰۱); RVECi compared to RME (P= ۰.۰۰۰۱), RVE and Ci (P= ۰.۰۰۰۱). It was also observed a significant decrease in HOMA-IR in the RME (P= ۰.۰۱۴), RVE (P= ۰.۰۰۱), Ci (P= ۰.۰۴۴), RMECi (P= ۰.۰۰۰۱), and RVECi (P= ۰.۰۰۰۱) compared to group C. Conclusion: Combining exercise with cinnamon may help prevent or delay T۲D complications. RVE exercise showed greater improvements in irisin and HOMA-IR than RME.

کلیدواژه ها:

Cinnamomum ، Diabetes mellitus ، Exercise ، FNDC۵ protein ، Irisin ، Metrnl protein