Development of Modified Electrode-Based Electrochemical Sensing Platform for the Voltammetric Determination of Imatinib

The present work describes a simple strategy for imatinib determination on the voltammetry basis. This strategy was established through a simple process for modification of screen-printed carbon electrode (SPCE) using nickel-cobalt layered double hydroxide hollow nanostructures (Ni-Co LDH HNSs). The cyclic voltammetry (CV) studies demonstrated a well-defined oxidation peak for imatinib at ۵۷۰ mV with improved response peak current (۱۳.۳ µA) at the surface of Ni-Co LDH HNSs/SPCE compared to unmodified SPCE. The electrochemical quantification of imatinib was conducted using differential pulse voltammetry (DPV). Under the optimum conditions, the modified SPCE exhibited good response for imatinib. The Ni-Co LDH HNSs/SPCE demonstrated a linear concentration range for imatinib (۰.۰۰۸ to ۹۰.۰ µM), with a low detection limit (LOD) of ۰.۰۰۵ µM. Finally, it was demonstrated that using a simple tool, the sensing platform could be an alternative strategy for analyzing the pharmaceutical products.

کلیدواژه ها:

Imatinib ، Drug analysis ، Electrochemical determination ، Layered double hydroxides ، Pharmaceutical formulations