Hyperthermia -Enhanced Drug Delivery Using ۳D -Printed Polycaprolactone /Hardystonite Scaffolds Coated with Mn -Zn Ferrite Nanoparticles

This study explores ۳D-printed composite scaffolds made of ۵۰ wt.% polycaprolactone (PCL) and ۵۰ wt.% hardystonite (HT) bioceramic nanoparticles for bone tissue engineering (BTE). Manganese-zinc ferrite (Mn₀.₅Zn₀.₅Fe₂O₄) nanoparticles, synthesized and loaded with doxorubicin (DOX), were incorporated into a chitosan coating on the scaffold. XRD and SEM analyses confirmed the structure and morphology of the nanoparticles. Hyperthermia studies showed that radiofrequency exposure increased the scaffold's temperature to ~۴۰°C, enhancing DOX release at ۴۰°C. These results highlight the potential of HT-enriched scaffolds with functional coatings for bone tumor treatment and tissue regeneration.

کلیدواژه ها:

Bone Tissue Engineering (BTE) ، ۳D-Printed Composite Scaffolds ، Manganese-Zinc Ferrite Nanoparticles ، Hyperthermia-Based Drug Delivery ، Hardystonite Bioceramics