Enhancing Tyrosine Reactivity in Silk Fibroin Nanoparticles for Advanced Drug Delivery Applications

Silk fibroin (SF) nanoparticles are biocompatible drug carriers, but rapid clearance limits their efficacy. Surface modifications, such as adding carboxyl groups, enhance their drug delivery potential. This study used diazonium coupling chemistry to functionalize SF with ۴-aminobenzoic acid diazonium salt at varying concentrations. UV-Vis and ¹H-NMR confirmed successful modifications, improving SF’s hydrophilicity and structural integrity. These advancements support SF’s application in targeted and sustained drug delivery systems.

کلیدواژه ها:

Silk fibroin nanoparticles ، Tyrosine modification ، Biomaterial