Association of BDNF Val۶۶Met polymorphism with Amphetamine and Opioid dependency in Azeri population of Iran: A case- control study

Background: Emerging evidence suggests a link between the Val۶۶Met polymorphism of brain-derived neurotrophic factor (BDNF) and an increased risk of neurobehavioral disorders (reference here). The present study aims to elucidate the potential relationship between this genotype and the predisposition to amphetamine and opiate dependencies among the Iranian Azeri population. Through rigorous analysis and comprehensive genetic profiling, this research endeavors to contribute valuable insights into the complex interplay between genetic factors and substance dependency in this specific ethnic group. Methods: A cohort of ۱۵۰ participants was recruited for this study, consisting of ۱۳۳ males and ۱۷ females in the treatment group, alongside ۱۰۰ controls, comprising ۷۴ males and ۲۶ females. Genotyping procedures utilized PCR-RFLP genotyping. Results: Comprehensive analysis revealed no statistically significant differences in the distribution of genotypes and alleles of the BDNF gene polymorphism (rs۶۲۶۵) between the case and control cohorts. The control group’s GG and AA genotypes were higher than the case group’s, while the control group’s AG genotype was lower than the case group’s, but statistically significant difference was not showed (p > ۰.۰۵). Conclusion: The outcomes of this rigorously designed study fail to substantiate a significant correlation between the Val۶۶Met polymorphism of the BDNF gene and the susceptibility to amphetamine and opiate dependency. This finding adds a new piece of the puzzle to our understanding of genetic predispositions in substance dependence.

کلیدواژه ها:

Amphetamine ، Addiction ، BDNF gene ، Opiate ، Val۶۶Met