Assessment of the association between sociodemographic characteristics and response to vitamin D supplementation using artificial neural network

Introduction: The serum ۲۵(OH)D response to vitamin D supplementation, differs  between individuals. The goal of this study was the evaluation of the relationship  between socioeconomic and demographic factors with the hugeness of response to  vitamin supplementation, defined by statistical analysis artificial neural network  (ANNs).  Methods: The prospective interventional study was conducted on ۵۲۹ participants  aged ۱۹-۱۲ years old. All participants were administrated to receive nine vitamin  D capsules (۵۰۰۰۰IU vitamin D) over nine weeks. The response variables were the  following: the differences between the concentrations of vitamin D before and after  intervention. Results: Among various sociodemographic factors which affect the increase in  serum vitamin D amounts in response to supplementations, baseline serum vitamin  D (%۲۸.۱), BMI (%۱۳.۸), physical activity (%۱۲.۱), age (%۷.۶), mother›s education  (%۶.۴), and father›s occupation (%۵.۸) be important variables.  Conclusion: This interventional study provides specific sociodemographicrecommendations to achieve ۲۵(OH)D targets in cases with severe vitamin D  deficiency, perhaps indicating that a higher dose is require to obtain optimal Vit D  levels in some individuals.

کلیدواژه ها:

lifestyle ، Socioeconomic ، adolescent girls ، Artificial neural network ، vitamin D supplementation