Potential of Lavender extract to inhibit efflux pump AdeB in multidrug resistant of Acinetobacter baumannii

Acinetobacter baumannii is one of the six most dangerous multidrug-resistant pathogens in hospitals across the globe which estimated ۱۰% of hospital-acquired infections are thought to be caused by this bacterium. Currently, up to ۴۳% of clinical isolates of A. baumannii have become resistant to at least three different antibiotic classes. Efflux pumps, particularly those belonging to the resistance-nodulation-division (RND) superfamily, significantly contribute to MDR in Gram-negative bacteria. The AdeABC efflux pump is a key player in A. baumannii antibiotic resistance, comprising AdeB (an RND transporter), AdeA (a periplasmic membrane fusion protein), and AdeC (an outer membrane factor protein). Given the reported antimicrobial activity of lavender's chemical constituents, this study investigated the potential of lavender compounds to inhibit the AdeABC pump in A. baumannii.

کلیدواژه ها:

Lavender extract ، efflux pump ، AdeB ، multidrug resistant ، Acinetobacter baumannii