Simultaneous overexpression of CD۷۰ and downregulation of CD۸۴ as a prognostic marker for glucocorticoid resistance in B cell Acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a type of blood cancer originating from lymphocytes of the immune system that spreads rapidly. ALL is one of the most common cancers in children with an increasing annual rate, although it also occurs in adults. Glucocorticoids, particularly Prednisolone and Dexamethasone, are highly valuable in the treatment of ALL. This importance is primarily due to their ability to induce apoptosis in cancer cells through glucocorticoid receptor activation. However, cancer cell resistance often disrupts their effectiveness. Studying the causes and patterns of drug resistance can aid in accelerating the replacement of treatment protocols and combating this phenomenon. In this study, transcriptomics data were used to compare gene expression levels in glucocorticoid-resistant and sensitive cell lines.

کلیدواژه ها:

drug resistance ، glucocorticoids ، acute lymphoblastic leukemia ، transcriptomics ، prognostic marker