Voltammetric Quantification of Idarubicin Through the Modification of Carbon Paste Electrode: A Strategy in Drug Monitoring

In this study, we evaluated the electrochemical performance of a carbon paste electrode (CPE) modified with CoMoO۴ nanosheets (NSs) and ionic liquid (IL) for the detection of idarubicin (IDR). We began by characterizing the CoMoO۴ NSs using field emission scanning electron microscopy (FE-SEM) and Fourier transform infrared spectroscopy (FT-IR) before incorporating them into the CPE . The electrocatalytic performance of the CoMoO۴ NSs/IL/CPE for the electrochemical oxidation of IDR was assessed using voltammetric techniques, including cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamprometry. We optimized key parameters to achieve the best results . The diffusion coefficient (D) was calculated using chronoamperometry. Under optimal conditions, DPV demonstrated a linear detection range (LDR) of ۴.۰ to ۲۰۰۰.۰ nM for IDR, with a detection limit (LOD) of ۱.۲ nM at CoMoO۴ NSs/IL/CPE. Furthermore , the CoMoO۴ NSs/IL/CPE was utilized to quantify IDR in real sample of idarubicine injection , yielding satisfactory results.

کلیدواژه ها:

cancer ، Chemotherapy ، Idarubicin ، Electrochemical sensor ، Carbon paste electrode ، CoMoO۴ nanosheets ، Ionic Liquid