Genotyping of ARNTL and CLOCK Circadian Rhythm Gene Polymorphisms in Iranian Patients with Multiple Sclerosis

Multiple sclerosis (MS) is a central nervous system disease accompanied by variable symptoms such as optic neuritis, fatigue, spasticity, neuro-urological dysfunction, paresthesia, and headache. The frequency of MS was reported differently in geographical latitude, which may be in relation to genetic changes in circadian rhythm regulator genes, including aryl hydrocarbon receptor nuclear translocator-like (ARNTL) and circadian locomotor output cycles kaput (CLOCK). This study aimed at genotyping rs۳۷۸۹۳۲۷ in the ARNTL and rs۶۸۱۱۵۲۰ in the CLOCK genes and their association with MS in the Iranian population.

کلیدواژه ها:

Multiple Sclerosis ، ARNTL ، CLOCK ، Polymorphism ، Iran