Polymeric Nanoparticles in Cancer Therapy: Drug Delivery through Controlled and Targeted Release - A Review

Over the past ۵۰ years, biodegradable polymers have revolutionized drug delivery and medical applications, particularly in cancer treatment. Polymeric nanoparticles (PNPs) have emerged as a versatile platform for controlled and targeted drug delivery, addressing the limitations of traditional therapeutics. These advancements have led to significant improvements in bioavailability, reduced toxicity, and enhanced therapeutic outcomes. This paper explores the evolution of polymeric drug delivery systems, highlighting their ability to provide localized, sustained drug release and their responsiveness to physiological stimuli. Key materials such as liposomes, PLGA, chitosan, and amphiphilic copolymers are examined for their roles in enhancing drug solubility, stability, and targeting capabilities. The paper also discusses various mechanisms of drug release, including diffusion, erosion, and stimuli-responsive systems, offering insights into their potential to transform cancer treatment by improving the precision and efficacy of nanomedicine. Ongoing research continues to push the boundaries of polymer-based drug delivery, promising to shape the future of personalized cancer therapy.

کلیدواژه ها:

Targeted Drug delivery ، Cancer Therapy ، Polymeric Nanoparticles (PNPs) ، Biodegradable Polymers ، Controlled Drug Release