Response of Serum Levels of Adiponectin and Insulin Resistance Indexes in Obese Male Rats to Two Types of Aerobic Exercise Intensities

Aims: Adiponectin is mainly produced by adipose tissue and there is an inverse relationship between circulating adiponectin levels and metabolic syndrome, obesity, and cardiovascular disease. The aim of the current study was to investigate the effects of eight weeks aerobic exercise with moderate and high intensities on serum levels of adiponectin and insulin resistance indexes in obese male rats. Materials & Methods: In this experimental study, ۲۴ adult obese male Wistar rats (weight ۲۵۰ to ۳۰۰g, BMI>۳۰g/cm۲) are divided into three groups including aerobic exercise with ۲۸m/min (MI= moderate intensity), aerobic exercise with ۳۴m/min (HI= high intensity) and, control group (C= control). All training groups carried out exercise training for ۸ weeks (۵ sessions per week for ۶۰ min per session). T-test and one-way analysis of variance were used to evaluate the differences between intra- and intergroup means, respectively. Tukey test was applied to compare the groups as two by two. Findings: The levels of adiponectin in MI group (p= ۰.۰۴) and HI (p= ۰.۰۴) rather than C group were increased. Moreover, there are no differences between eight weeks aerobic exercise with MI and HI groups on adiponectin levels (p= ۱.۰۰). The levels of FBS and insulin in MI and HI groups rather than C group were reduced but these changes were not significant (p>۰.۰۵). The levels of insulin resistance index in MI group (p= ۰.۰۱) and HI (p= ۰.۰۱) rather than C group were significantly reduced. Conclusion: It seems that both of the aerobic exercise intensities have a better effect on the prevention of obesity and cardiovascular disease.

کلیدواژه ها:

Obesity ، Aerobic Training ، Adiponectin ، Insulin Resistance Index ، چاقی ، تمرین هوازی ، آدیپونکتین ، شاخص مقاومت به انسولین