Evaluation of the relationship between anti-Müllerian hormone, inhibin-b, testosterone, and semen parameters in cryptorchidism patients

Objective: Cryptorchidism is the most common deficiency of the male reproductive system and most prevalent endocrine disease of boys at birth. Insufficient prenatal anti-Müllerian hormone (AMH) secretion from Sertoli cells of the testis is one of its causes. The role of this hormone and inhibin B in fertility has recently been proven. AMH is a known indicator of Sertoli cell function. The aim of this study was to assess the relationship between anti-Müllerian hormone, inhibin B, testosterone, and semen parameters in post-pubertal cryptorchidism patients. Methods: We gathered the data of this cross-sectional study from blood and semen samples of ۲۰ patients who had a history of unilateral cryptorchidism. Patients, ۲۰-۴۰ years of age, referred to the Urology Ward of Shariati Hospital, Tehran, Iran. Serum levels of AMH, inhibin B and testosterone were analyzed by enzyme-linked immunosorbent assay. Semen analysis was performed by means of a computer aided semen analysis system ۶.۵.۰. Pearson’s correlation test was used to evaluate the relationships between variables. Result: Significant positive relationships were existed between total sperm motility and sperm concentration (r=۰.۰۸۶; p<۰.۰۱), total motility and fast progressive motility (r=۰.۹۷; p<۰.۰۱), sperm concentration and fast progressive motility (r=۰.۹; p<۰.۰۱), white blood cell count and sperm concentration (r=۰.۶۳; p<۰.۰۵), white blood cell count and sperm motility (r=۰.۶۶; p<۰.۰۵), white blood cell count and sperm fast progressive motility (r=۰.۷۷; p<۰.۰۱), and testosterone levels and serum AMH (r=۰.۶; p<۰.۰۱). Conclusion: Cryptorchidism patients in this study had lower serum concentrations of AMH, inhibin B and testosterone than the normal limits. Despite the positive correlation between serum testosterone and AMH, none of the investigated hormones showed any significant relationship with semen parameters.

کلیدواژه ها:

Anti-Müllerian Hormone ، Inhibin B ، Testosterone ، Cryptorchidism ، هورمون آنتی مولرین ، اینهیبین B ، تستوسترون ، کریپتورکیدیسم