۳-month physical activity and fat mass loss regulate breast cancer-related inflammatory markers in obese and overweight postmenopausal women

Chronic low-grade inflammation plays a role in the pathogenesis of several chronic diseases including cancer. exercise training have been supposed to modulate inflammatory markers. The effects of a concurrent training on gene expression TGF-β۱ was evaluated in an unblinded randomized controlled clinical trial .Thirty participants [healthy postmenopausal women with high breast density, age ۴۵-۵۵years, BMI >۲۵ kg/m۲, inactive and had an elevated Gail ۵-year risk score of breast cancer (>۱.۶۶%)] were randomized to two arms: training group (TG, n=۱۵) and control group (CG, n=۱۵). Participants took part in a ۱۲-week supervised intervention, ۵ days/week training and ۶۰ min/session. Before and after the intervention, body composition was assessed, and blood samples were obtained to evaluate estradiol, TGF-β۱. In response to training, a reduction in total fat mass was found (۵.۳%; P<۰.۰۵), while an increase in lean body mass was observed in the TG group (۱.۵%; P<۰.۰۵). The expression of the TGF-β۱ gene decreased, but this change was not statistically significant (P>۰.۰۵). The exercise training and in fact, exercise-induced fat mass loss seem to modify the pro inflammatory markers in postmenopausal women that is an established risk factor of breast cancer. Thus, this study provides additional evidences to the intricate interaction among cytokines, adipose tissue, and muscle mass in postmenopausal women.

کلیدواژه ها:

Body composition ، Breast cancer prevention. concurrent Training. Transforming growth factor-beta ۱. Menopause