Discovery of Genes Differentially EXpressed in Gastric Cancer

Gastric cancer is one of the most common causes of cancer-related death worldwide, and the molecular mechanisms involved in gastric carcinogenesis are still not fully understood. Insufficient knowledge about the molecular elements involved in the disease has hindered development of diagnostic/prognostic biomarkers. Thus, patients are diagnosed at higher stages, which leads to a poor prognosis for these patients. This study aimed to determine highly expressed genes in ۱۱۱ human gastric cancer tissues compared to ۲۱ non-cancerous gastric tissues by high-density oligonucleotide microarray. The data of the study of Query DataSets-GSE۵۴۱۲۹ from NCBI Under the platform Affymetrix Human Genome U۱۳۳ Plus ۲.۰ Array were extracted and analyzed. In this study, ۱۰۳۶ genes were highly over-expressed (logFC>۰) in cancerous tissue was compared to tissue from healthy people. Conclusion: The highly over-expressed gene patterns and some important genes were identified, which might be useful in further study on carcinogenesis, progression, and metastasis of GC.

کلیدواژه ها:

gene expression ، Gastric cancer ، microarray ، biomarkers ، biostatistics