Efficient One-Pot Preparation of ۲,۴-Dichloro-substituted Pyrano [۲,۳-d]pyrimidines and Furo[۲,۳-d]pyrimidines Mediated by Ceric Ammonium Nitrate in phosphorus ionic liquid

An efficient, green, and facile four-component reaction for the preparation of ۲,۴-dichlorosubstituted pyrano [۲,۳-d]pyrimidines and furo[۲,۳-d]-pyrimidines through the one-pot condensation of acetophenone derivatives, various aromatic aldehydes (or potassium iodide), malononitrile and carbon tetrachloride is reported. The cerium (IV) ammonium nitrate (CAN) was used as a single electron oxidant and ionic liquid (HTPB) as a green promoter at ambient temperature. The major advantages of this methodology are experimentally simplicity, environmentally benign, non-toxic and inexpensive catalyst, simple workup procedure, without using column chromatography, all of the compounds were isolated in analytically pure form, excellent yields and short reaction times.

کلیدواژه ها:

green chemistry ، Cerium(IV) ammonium nitrate ، Ionic liquid ، Pyrano[۲ ، ۳-d]pyrimidines ، Furo[۲ ، ۳-d]-pyrimidines ، One-pot