Evaluation of Anti-Psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-Like Dermatitis in Mice

Objectives: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has a high pharmacological activity and is historically used to treat psoriasis and other skin conditions. This study aims to evaluate the Aloe sinkatana plant's anti-psoratic properties. Methods: The Imiquimod-induced psoriasis mice model was used to evaluate to the antipsoriatic effect of the Aloe sinkatana plant; the effects of ۰.۱% & ۰.۲% extracts of Aloe sinkatana extract on five groups of mice were used, and compared with the conventional medication Dexamethasone   Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentage of psoriasis-like symptoms was reduced in groups treated with ۰.۲% Aloe extract, ۰.۱% Aloe extract & dexamethasone, was ۸۶%, ۸۴%, and ۶۸%, respectively. Both extract concentrations also improved the psoriatic lesions and decreased the grading of the treated groups' psoriasis area and severity index (PASI) scale. Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by Aloe sinkatana extract and it may be beneficial in the pharmaceutical formulation of new safe and effective medication for the treatment of psoriasis.

کلیدواژه ها:

Aloe sinkatana ، Dermatitis ، Extracts ، Imiquimod ، psoriasis area and severity index (PASI) ، Mice