Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study

Background: Gastric cancer (GC) is the most common cancer among Iranian men. A diet rich in antioxidant compounds has been offered as an appropriate strategy for reducing the risk of GC. This study aimed to determine the possible association between dietary total antioxidant capacity (dTAC) and the Iranian population's GC risk. Methods: In total, ۱۷۸ newly diagnosed GC patients and ۲۳۸ healthy controls were recruited for this hospital-based case-control study. Dietary intakes were collected using a validated ۱۴۶-item diet history questionnaire (DHQ), and dTAC was analyzed using Ferric reducing antioxidant potential (FRAP) assay. Results: The mean value of dTAC was ۱۰.۴۲±۵.۴۲ for cases and ۱۱.۴۲±۵.۸۶ for controls. Black tea, fruits, and cereals consumption were the main contributors to dTAC in both groups. DTAC was associated with a reduction in the risk of GC (OR ۰.۵۴; ۹۵%CI: ۰.۳۱–۰.۹۲) (second vs. lowest tertile). This association did not change after adjustment for body mass index, education, energy intake, smoking, and Helicobacter pylori infection (۰.۵۵; ۹۵% CI: ۰.۳۱-۰.۹۹). There was no significant association between fruits, vegetables, nuts, and legumes TAC with GC. Conclusion: The whole intake of dTAC from different food sources was not high in the population; however, this amount showed a preventive effect against GC.

کلیدواژه ها:

Case-Control ، Diet ، FRAP ، Stomach neoplasms ، Total antioxidant capacity.