Study role of age in contact dependent transmission of Mycobacterium tuberculosis in northwest of Iran by IS۶۱۱۰-RFLP method

Objective: The present study investigated the role in transmission of M. tuberculosis strains isolated from tuberculosis patients residing in Northwest (East and West Azarbaijan) of Iran. Materials and Methods: We performed restriction fragment length polymorphism analysis on IS۶۱۱۰ of M. tuberculosis isolated from Northwest Iran. Total of ۱۶۵ isolates of M. tuberculosis were analyzed by RFLP method. Results: The ۵ copies and more IS۶۱۱۰ isolates comprised ۳۰.۵۲% of the total isolates. They formed ۱۶ clustered groups consisting of ۲ to ۱۰ cases each. ۶۹.۴۸% of patients had a unique RFLP patterns. Cases from male patients were more clustered than female patients but statistically was not significant (P>۰.۰۵). In this study patients with ۵۶ and older age were strongly associated with clustering (۵۹.۶%), which were significantly more than younger patients (P<۰.۰۵). Conclusion: In the present study we found old age as a major risk factor in contact dependent transmission of TB compared to disease recurrence. Unemployment and poor living condition were also among the risk factors in transmission of tuberculosis.

کلیدواژه ها:

IS۶۱۱۰ ، RFLP ، Mycobacterium tuberclosis ، Age ، Transmission ، مایکوباکتریوم توبرکلوزیس ، سن ، انتقال