Evaluation And Diagnosis Of Pancreatic Cancer And Investigation Of Its Related Genetic Factors"

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a global incidence of nearly ۲۰۰,۰۰۰ new cases annually and a five-year survival rate below ۵%. This study explores the molecular mechanisms, potential biomarkers, and therapeutic approaches to improve early diagnosis and treatment outcomes for PDAC. Gene expression data from three datasets (GSE۲۸۷۳۵, GSE۱۵۴۷۱, GSE۶۲۴۵۲) were analyzed, identifying ۲۰۲ differentially expressed genes (DEGs) through GEO۲R, including ۱۴۷ upregulated and ۵۵ downregulated genes. Functional enrichment analyses highlighted extracellular matrix (ECM) organization, focal adhesion, and PI۳K-Akt signaling pathways as key contributors to PDAC progression. Hub genes such as COL۱A۱, COL۳A۱, COL۱A۲, FN۱, COL۵A۲, ITGA۳, and MET were identified, with ITGA۳ and MET demonstrating significant prognostic value, correlating with reduced patient survival. Treatment approaches, including surgery, chemotherapy, and gene therapy techniques such as RNA interference (RNAi) and genetic vectors, were explored for their therapeutic potential. This study underscores the critical role of ECM remodeling in PDAC and highlights ITGA۳ and MET as promising biomarkers for diagnosis and prognosis, offering avenues for targeted therapeutic strategies

کلیدواژه ها:

Pancreatic ، cancers ، therapeutic strategies