Antibiotics Resistance Patterns &Carbapenemase Genes Distribution of Klebsiella pneumoniea in Iran:A Review Article

Resistant Klebsiella pneumoniae to the latest solution (carbapenem antibiotics) distributed worldwide. The proliferation of carbapenemase genes among Klebsiella pneumoniae strains has led to their resistance to the carbapenem group. The aim of this study is to estimate antibiotic resistancepatterns and distribution of carbapenemase genes  of Klebsiella pneumoniea in Iran. PubMed, Scholar ,SID, and Iran civilica  databases were searched for the related articles that were published between ۱۹۹۹ and ۲۰۱۹. A total  of ۲۲۵ articles were found, out of which ۷۰ relevant articles were selected for complete evaluation. According to the results, the highest rates of drug resistance in Klebsiella pneumoniae were observed against aztreonam (۵۸%), cephalosporins family (۵۴%), and then SXT (۵۲%). The incidence rate of resistance was ۱۹% for carbapenems family (IMP, MER), ۳۷% for aminoglycosides family (GM, AN) and ۴۱% for quinolones family (FM, CIP). Among the genes encoding CRE during ۲۰۱۴–۲۰۱۹, OXA, KPC, NDM, VIM, IMP, and GES were found with a prevalence of ۳۹%, ۳۵%, ۱۸%, ۱۳%, ۱۱%, and ۳%, respectively. Conclusion: Carbapenem resistance and the production of the metallo-beta-lactamase enzyme in K. pneumoniae are increasing. Due to the presence of carbapenemase-producing genes and the possibility of horizontal transfer of these genes to other bacteria, combined with changing the patterns of antibiotic use, more attention should be paid to the predisposing criteria for controlling nosocomial infections.

کلیدواژه ها:

Klebsiella pneumoniae ، drug resistance ، Carbapenemase ، Iran