Serum Levels of Factor XIII, D-dimer, and Fibrinogen as A non-Invasive Diagnostic Biomarkers in Patients with Venous Thromboembolism

Background & Objective: Using new diagnostic methods to help quickly diagnose VTE disease is important. It is well known that treatment of VTE is based on radiological methods, but the main purpose of this research was to investigate the relationship between blood coagulation factor XIII( FXIII), D-dimer, and fibrinogen levels in patients with VTE.  Materials & Methods: Seventy patients initially suspected of having VTE were included and determined their D-dimer, fibrinogen, and (FXIII )levels. The diagnosis of VTE was based on the CT-Angiography. The blood samples were prepared from the patients during the first ۶ hours of admission and before using anticoagulant. Results: The mean level of D-dimer in VTE patients was higher than those without VTE (۱۷۷۰± ۷۶۴.۴۹ vs. ۴۳۰.۶۶± ۲۶۳.۹۸ng / ml) (p <۰.۰۰۱). The mean factor XIII level in patients with VTE was significantly lower than those without VTE(۵۵.۰۳±۱۳.۶۱ vs. ۸۸.۵۷±۱۸.۱۴ng / ml) (p <۰.۰۰۱). The mean fibrinogen level in patients with VTE was significantly lower than in non-VTE patients (۱۴۰.۴۹± ۳۶.۰۳ vs. ۲۱۴.۶۹± ۶۹.۷۳ mg/dl) (p <۰.۰۰۱). The cut-off value of D-dimer was ۵۰۰ ng/ml, and the sensitivity and specificity were ۹۷% and ۷۴%, respectively. The cut-off point of fibrinogen was ۱۶۸ mg/dl, with a sensitivity of and a specificity of ۷۷% and ۷۷%, respectively. The cut-off point of XIII was ۷۰ ng/ml, with a sensitivity of and specificity۸۵% and ۸۲%, respectively. Conclusion:  Our findings suggest that combined measurement of serum levels of D-dimer, factor XIII, and fibrinogen can be used to confirm clinical suspicion for VTE.

کلیدواژه ها:

D-dimer ، Fibrinogen ، Factor XIII ، Venous thromboembolism