The Effect of Coenzyme Q۱۰ on Tinnitus Severity and Sleep Quality in Patients with Presbycusis

Introduction: Tinnitus is one of the symptoms of presbycusis that affects patients' sleep and social life. This study aimed to determine the effect of coenzyme Q۱۰ (CoQ۱۰) on treating tinnitus due to presbycusis. Materials and Methods: In this double-blind, randomized clinical trial, ۵۰ patients with tinnitus due to presbycusis were randomly divided into groups A and B, with ۲۵ patients in each group. In addition to routine treatments, group A received ۱۰۰ mg of CoQ۱۰ daily, while group B received a placebo. Both groups were evaluated for tinnitus severity, loudness of tinnitus, quality of life, and sleep disturbance before and ۶ weeks after starting the treatment. Results: In the intervention and control groups, the mean changes in score compared to before the treatment were as follows: quality of life (۳.۱ ± ۱.۶۷) and (۱.۲۸ ± ۰.۷۶) (P = ۰.۲۹۸), sleep disorder (-۷.۶۰ ± ۱.۳۸) and (-۱.۰ ± ۸.۵۵) (P<۰.۰۰۱), tinnitus disability (-۱۷.۲ ± ۵۲.۹۳) and (-۴.۵۶ ± ۱.۳۷) (P<۰.۰۰۱), tinnitus loudness of right ear (-۱.۶۸ ± ۰.۴۱) and (-۰.۹۵ ± ۰.۲۳) (P=۰.۱۱) and left ear (-۲.۲ ± ۰.۳۵) and (-۰.۵۴ ± ۰.۲۱) (P<۰.۰۰۱). Conclusion: This study indicated that adding CoQ۱۰ to the routine regimen for patients with tinnitus due to presbycusis significantly decreases tinnitus disability, improves sleep disturbance, and reduces tinnitus loudness. However, more studies should be conducted in this regard.

کلیدواژه ها:

Coenzyme Q۱۰ ، Presbycusis ، Tinnitus