Overview of Targeted Therapy for Retinoblastoma

سال انتشار: 1403
محل انتشار: دومین کنگره بین المللی کنسرژنومیکس
کد COI اختصاصی: ICGCS02_049
زبان مقاله: انگلیسی
تعداد مشاهده: 156

نویسندگان

The Student Research Committee of Lorestan University of Medical Sciences, Khorramabad, Iran

چکیده

Retinoblastoma is a malignant tumor of the retina that predominantly affects young children, with incidence rates of approximately ۱ in ۱۵,۰۰۰ live births. Traditionally, intensive treatment strategies, including chemotherapy, radiotherapy, and surgical interventions, have been employed in the management of retinoblastoma. However, these conventional approaches often bring significant adverse effects and do not address the underlying genetic etiology of the disease. Recent advances in molecular biology and genetics have paved the way for the development of targeted therapies aimed at improving treatment outcomes while minimizing toxicity. This article presents an overview of the current state of targeted therapies for retinoblastoma, focusing on the molecular pathways involved in tumorigenesis and the potential therapeutic targets that have emerged from recent research. In retinoblastoma, the inactivation of the RB۱ gene is a pivotal event, leading to uncontrolled cell proliferation. Targeted therapy seeks to intervene in this aberrant signaling cascade, utilizing agents that specifically inhibit pathways commonly activated in retinoblastoma cells. These include therapies directed against the Cyclin D/CDK۴/۶ pathway, the PI۳K/AKT/mTOR signaling pathway, and the MYCN oncogene, among others. Additionally, the potential role of immunotherapy in retinoblastoma is explored, highlighting the significance of the tumor microenvironment and the immune response in the progression of the disease. The integration of immune checkpoint inhibitors and other immunomodulatory agents represents a promising frontier in the treatment landscape for retinoblastoma. Furthermore, this article discusses the challenges and limitations associated with the implementation of targeted therapies, including the necessity for precise molecular characterization of individual tumors and the potential for the development of drug resistance. The importance of clinical trials in evaluating the efficacy and safety of these novel approaches is emphasized, as well as the need for multidisciplinary collaboration in advancing the field of pediatric oncology. In summary, targeted therapy represents a paradigm shift in the treatment of retinoblastoma, offering the promise of improved outcomes and quality of life for affected children. This article aims to provide a comprehensive analysis of the current understanding of targeted treatment options, their implications for clinical practice, and the future directions of research in retinoblastoma management. Through continued exploration and innovation, the goal is to refine therapeutic strategies that are both effective and tailored to the specific genetic profiles of retinoblastoma patients, ultimately transforming the prognosis of this devastating disease.

کلیدواژه ها

Retinoblastoma, TargetedTherapy, PediatricOncology, CancerCare, OncologyAdvancements

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