Albumin-Loaded Nanofiber for Topical Wound Healing

Objective: Intravenous albumin administration increases blood circulation and enhances wound healing. Topical application of albumin can inhibit the growth of certain bacteria on topical wounds. Topical caffeine can induce vascularization and the formation of blood vessels on the skin. The purpose of this work is to explore for the first time the effect of topical albumin and caffeine on wound healing rate in rat models. Methods: This work aimed to develop albumin and caffeine-loaded nanofibers by the electrospinning method and to evaluate their topical effect on wound healing.  Nanofiber formation was assessed by SEM and considered using FT-IR spectroscopy. The therapeutic activity of topical albumin and caffeine was investigated on a full-thickness excision skin model.   Results: Albumin alone or in combination with caffeine effectively reduced the exposed wound area.  Wound contraction at the end of week ۲ was higher in albumin and caffeine loaded nanofiber group (۹۶%) relative to the control group (۷۹%). Conclusion: Data show that daily albumin-loaded wound dressing displayed good healing properties and enhanced wound closure rate. These findings may indicate the successful application of the sauce as a promising tool in wound healing therapy.

کلیدواژه ها:

Albumin ، caffeine ، nanofiber ، wound healing